The research interests of Dr. Bizios are in the areas of cellular bioengineering, biomaterials and tissue engineering.
Cultured mammalian cells have been used in the lab to study events which take place at the tissue/implant interface under various chemical, mechanical and electromagnetic stimuli. Currently the research focuses on the following: modification of the surfaces of implant biomaterials to promote and/or control specific, desirable and timely responses from cells and tissues; optimization of cell culture conditions (that is, chemical, mechanical, electromagnetic) to obtain formation of mineralized deposits by osteoblasts; study of bone cell (that is, osteoblast, osteocyte and osteoclast) function under cyclic loading; examination of bladder smooth muscle cell responses to sustained hydrostatic pressure; determination of the molecular mechanism(s) of endothelial cell responses to sustained hydrostatic pressure; and investigation of vascular (that is, endothelial and smooth muscle) cell responses to sustained and cyclic mechanical forces.
The results of these studies provide valuable insights at the cellular/molecular level of physiological processes (such as tissue regeneration and remodeling) and of select pathological conditions. The knowledge derived from this research could be used to design the orthopaedic/dental implant biomaterials of the future and to develop new strategies to engineer tissue formation in vitro and in vivo.