Publications

Selected Publications

1) “Nanotube-Assisted Protein Deactivation”, Nature Nanotechnology, 2008, 3, 41-45.

2) “Raftlike Polyvalent Inhibitors of the Anthrax Toxin: Modulating Inhibitory Potency by Formation of Lipid Microdomains,”

Angewandte Chemie International Edition, 2007, 46, 2207.

3) “Polymer-Nanotube-Enzyme Composites as Active Antifouling Films”, Small, 2007, 3, 50-53. Highlighted in Nature Nanotechnology.

4) “Statistical Pattern Matching Facilitates the Design of Polyvalent Inhibitors of Anthrax and Cholera Toxins”, Nature Biotechnology,

2006, 24, 582.

5) “Polyvalent Inhibitors of Anthrax Toxin that Target Host Receptors”, Proceedings of the National Academy of Sciences, USA,

2006, 103, 13509.

6) “Polyvalency: Recent Developments and New Opportunities for Chemical Engineers”, AIChE Journal, 2006, 52, 3638.

7) “Capillarity Driven Assembly of Two-dimensional Cellular Carbon Nanotube Foams,” Proceedings of the National Academy of

Sciences, USA, 2004, 101, 4009. Featured on the cover.

8) “Directed Assembly of Carbon Nanotubes at Liquid-Liquid Interfaces: Nanoscale Conveyors for Interfacial Biocatalysis”,

Journal of the American Chemical Society, 2006, 128, 1046.

9) “Designing a Polyvalent Inhibitor of Anthrax Toxin,” Nature Biotechnology, 2001, 19, 958. Featured in Nature’s special online

focus on bioterrorism.

10) “Kosmotropes Form the Basis of Protein-Resistant Surfaces,” Langmuir, 2003, 19, 2388.

11) “Solving Mazes Using Microfluidic Networks,” Langmuir, 2003, 19, 4714. Featured in Nature’s News and Views in Brief.

12) “Patterned Deposition of Cells and Proteins onto Surfaces by Using Three-dimensional Microfluidic Systems,” Proceedings of the

National Academy of Sciences, USA, 2000, 97, 2408.

13) “Patterning Proteins and Cells Using Soft Lithography,” Biomaterials, 1999, 20, 2363. Featured in the Biomaterials Silver

Jubilee Compendium as one of the 25 most significant papers published in Biomaterials over the last 25 years

Complete List

77) Joshi, A.; Punyani, S.; Bale, S. S.; Yang, H.; Borca-Tasçiuc, T.; Kane, R. S., “Nanotube-Assisted Protein Deactivation”,

Nature Nanotechnology, 2008, 3, 41-45.

76) Kane, R. S. “Fabricating complex polymeric micro- and nanostructures: Lithography in microfluidic devices”, Angewandte Chemie

International Edition, 2008, 47, 8, 1368-1370.

75) Rai, P.; Vance, D.; Poon, V.; Mogridge, J.; Kane, R. S. “Stable and Potent Polyvalent Anthrax Toxin Inhibitors: Raft-inspired

Domain Formation in Liposomes Containing PEGylated Lipids”, Chemistry – A European Journal, 2008, in press.

74) Vance, D.; Shah, M.; Joshi, A.; Kane, R. S. “Polyvalency: A Promising Strategy for Drug Design”, Biotechnology & Bioengineering,

2008, in press.

73) Joshi, A.; Vance, D.; Rai, P.; Thiyagarajan, A.; Kane, R. S. “The Design of Polyvalent Therapeutics”, Chemistry – A European Journal,

2008, in press.

72) Vutukuru, S.; Kane, R. S. “Surface Plasmon Resonance Spectroscopy-Based High-Throughput Screening of Ligands for

use in Affinity and Displacement Chromatography”, Langmuir, 2008, in press.

71) Vutukuru, S.; Kate, S. D.; McCallum, S. A.; Morrison, C. J.; Cramer, S.M.; Kane, R. S. “An Affinity-Based Strategy for the

Design of Selective Displacers for the Chromatographic Separation of Proteins”, Langmuir, 2008, 24, 13, 6768-6778.

70) Shah, D.; Pangule, R. C.; Bale, S. S.; Asuri, P.; Joshi, A.; Banerjee, A.; Vance, D.; Dordick, J. S.; Kane, R. S.

“Preparation and Characterization of Carbon Nanotube-Protein Conjugates”, 2008, manuscript submitted.

69) Frost, M.; Rai, P.; Poon, V.; Kane, R. S.; Mogridge, J. “A Polyvalent Inhibitor of Anthrax Toxin Based on a Retro-Inverso Peptide”,

2008, manuscript submitted.

68) Gujraty, K. V.; Yanjarappa, M. J.; Saraph, A.; Joshi, A.; Mogridge, J. ; Kane, R. S. “Synthesis of Hompolymers and Copolymers

Containing an Active Ester of Acrylic Acid by RAFT: Scaffolds for Controlling Polyvalent Ligand Display”, 2008, manuscript submitted.

67) Pangule, R. C.; Bale, S. S.; Shah, D. A.; Joshi, A.; Asuri, P.; Dordick, J. S.; Kane, R. S. “Biomolecule-Nanomaterial Interactions: Effect

on Biomolecule Structure, Function, and Stability”, 2008, manuscript submitted.

66) Rai, P. R.; Saraph, A.; Ashton, R.; Poon, V.; Mogridge, J.; Kane, R. S. “Raftlike Polyvalent Inhibitors of the Anthrax Toxin:

Modulating Inhibitory Potency by Formation of Lipid Microdomains,” Angewandte Chemie International Edition, 2007, 46, 2207.

65) Kaur, S; Sahoo, S.; Ajayan, P.; Kane, R. S. “Capillarity-Driven Assembly of Carbon Nanotubes on Substrates into Dense

Vertically Aligned Arrays”, Advanced Materials, 2007, 19, 2984.

64) Asuri, P.; Karajanagi, S. S.; Kane, R. S.; Dordick, J. S. “Polymer-Nanotube-Enzyme Composites as Active Antifouling Films”,

Small, 2007, 3, 50-53. Highlighted in Nature Nanotechnology.

63) Kane, R. S.; Stroock, A. D. “Nanobiotechnology: Protein-Nanomaterial Interactions,” Biotechnology Progress, 2007, 23, 316-319.

62) Koerber, J. T.; Jang, J-H.; Yu, J. H.; Kane, R. S.; Schaffer, D. V. “Engineering Adeno-Associated Virus for One-Step

Purification via Immobilized Metal Affinity Chromatography,” Human Gene Therapy, 2007, 18, 367-378.

61) Ashton, R. S.; Peltier, J.; Fasano, C.; O’Neill, A.; Leonard, J.; Temple, S.; Schaffer, D. V.; Kane, R. S. “Clonal

Microarrays: High-Throughput Screening of Gene Function in Stem Cells”, Stem Cells, 2007, 25, 2928.

60) Bale, S. S.; Asuri, P.; Karajanagi, S. S.; Dordick, J. S.; Kane, R. S. “Protein-Directed Formation of Silver Nanoparticles on Carbon

Nanotubes”, Advanced Materials, 2007, 19, 20, 3167.

59) Asuri, P.; Bale, S. S.; Pangule, R. C.; Shah, D. A.; Kane, R. S.; Dordick, J. S. “Structure, Function, and Stability of Enzymes

Covalently Attached to Single-Walled Carbon Nanotubes”, Langmuir, 2007, 23, 24, 12318.

58) Ashton, R. S.; Banerjee, A.; Punyani, S.; Schaffer, D. V.; Kane, R. S. “Scaffolds based on Degradable Alginate Hydrogels

and Poly (lactide-co-glycolide) Microspheres for Stem Cell Culture”, Biomaterials, 2007, 28, 36, 5518.

57) Li, X.; Chen, H.; Lauterbach, S. B.; Lanzillotti, R.; Rai, P. R.; Kane, R. S.; Coetzer, T. L.; Chishti, A. H. “Receptor-Based Identification

of a Novel Peptide Inhibitor Against Blood Stage Malaria”, 2007, manuscript submitted.

56) Suhr, J.; Joshi, A..; Schadler, L.; Kane, R. S.; Koratkar, N. A. “Effect of Filler Geometry on Interfacial Friction Damping in

Polymer Nanocomposites”, Journal of Nanoscience and Nanotechnology, 2007, 7, 1684-1687.

55) Asuri, P.; Karajanagi, S. S.; Dordick, J. S.; Kane, R. S.; “Enhanced Stability of Enzymes Adsorbed onto nanoparticles”,

Journal of Nanoscience and Nanotechnology, 2007, 7, 1675-1678.

54) Rai, P.; Padala, C.; Poon, V.; Saraph, A.; Basha, S.; Kate, S.; Tao, K.; Mogridge, J.; Kane, R. S. “Statistical Pattern Matching

Facilitates the Design of Polyvalent Inhibitors of Anthrax and Cholera Toxins”, Nature Biotechnology, 2006, 24, 582.

53) Basha, S.; Rai, P.; Poon, V.; Saraph, A.; Gujraty, K.; Go, M.; Sadacharan, S.; Frost, M.; Mogridge, J.; Kane, R. S. “Polyvalent

Inhibitors of Anthrax Toxin that Target Host Receptors”, Proceedings of the National Academy of Sciences, USA, 2006, 103,

13509.

52) Kane, R. S. “Polyvalency: Recent Developments and New Opportunities for Chemical Engineers”, AIChE Journal, 2006, 52, 3638.

51) Padala, C.; Cole, R.; Kumar, S.; Kane, R. S. “Lipid Mobility Controls the Diffusion of Small Biopolymer Adsorbates”,

Langmuir, 2006, 22, 6750.

50) Kesapragada, S. V.; Yim, T-J.; Dordick, J. S.; Kane, R. S.; Gall, D. “Selective Assembly of Multi-component Nanosprings

and Nanorods,” manuscript submitted.

49) Rege, K.; Yang, T.; Sharfstein, S. T.; Kane, R. S.; Cramer, S. M. “Parallel Synthesis and Screening of Polymeric Transfection

Agents for Non-Viral Gene Delivery,” manuscript submitted.

48) Zhang, W.; Joshi, A.; Wang, Z.; Kane, R. S.; Koratkar, N. “Creep Mitigation in Composites Using Carbon Nanotube

Additives,” Nanotechnology, 2007, 185703.

47) Gujraty, K.; Ashton, R.; Reddy, B. S.; Kate, S.; Faulkner, C. J.; Jennings, K.; Kane, R. S. “Thiol-Mediated Anchoring of

Ligands to Self-Assembled Monolayers for Studies of Biospecific Interactions”, Langmuir, 2006, 22, 10157.

46) Vutukuru, S; Reddy, B. S.; Kane, R. S. “Protein Adsorption on Well-Defined Multi-Modal Surfaces Based on Self-Assembled

Monolayers,” Langmuir, 2006, 22, 10152.

45) Kaur, S.; Ajayan, P.; Kane, R.S. “Design and Characterization of Three-dimensional Carbon Nanotube Foams”, Journal of

Physical Chemistry B, 2006, 110, 21377.

44) Asuri, P.; Karajanagi, S. S.; Kane, R. S.; Dordick, J. S. “Increasing Protein Stability Through Control of the Nanoscale

Environment”, Langmuir, 2006, 22, 5833.

43) Joshi, A.; Saraph, A.; Poon, V.; Mogridge, J.; Kane, R. S. “Synthesis of Potent Inhibitors of Anthrax Toxin based on Poly-L-Glutamic Acid”,

Bioconjugate Chemistry, 2006, 17, 1265.

42) Asuri, P.; Bale, S. S.; Karajanagi, S. S.; Kane, R. S. “The Protein-Nanomaterial Interface”, Current Opinion in Biotechnology, 2006,

17, 562-568 (invited contribution).

41) Jiang, X.; Takayama, S.; Chapman, R. G.; Kane, R. S.; Whitesides, G. M. “Micro-Scale Patterning of Cells and Their Environment”,

Book chapter in Principles of Tissue Engineering, 3rd Ed.; Ed: R. Lanza, R. Langer, J. Vacanti, in press.

40) Karajanagi, S. S.; Asuri, P.; Sellitto, E.; Eker, B.; Bale, S. S.; Kane, R. S.; Dordick, J. S. “Protein-Carbon Nanotube Conjugates”,

ACS Symposium Series, in press.

39) Gujraty, K. V.; Joshi, A.; Saraph, A.; Poon, V.; Mogridge, J.; Kane, R. S. “Synthesis of Polyvalent Inhibitors of Controlled Molecular

Weight: Structure-Activity Relationship for Inhibitors of Anthrax Toxin”, Biomacromolecules, 2006, 7, 2082.

38) Yanjarappa, M. J.; Gujraty, K. V. ; Joshi, A. ; Saraph, A. ; Kane, R. S. “Synthesis of Copolymers Containing Active Ester Groups by

RAFT: Controlled Molecular Weight Scaffolds for Biofunctionalization”, Biomacromolecules, 2006, 7, 1665.

37) Asuri, P.; Karajanagi, S. S.; Sellitto, E.; Kim, D.-Y.; Kane, R. S.; Dordick, J. S. “Water-Soluble Carbon Nanotube-Enzyme Conjugates

as Functional Biocatalytic Formulations”, Biotechnology and Bioengineering, 2006, 95, 804.

36) Asuri, P.; Karajanagi, S. S.; Dordick, J. S.; Kane, R. S. “Directed Assembly of Carbon Nanotubes at Liquid-Liquid Interfaces:

Nanoscale Conveyors for Interfacial Biocatalysis”, Journal of the American Chemical Society, 2006, 128, 1046.

35) Karajanagi, S. S.; Yang, H.; Asuri, P.; Sellitto, E.; Dordick, J. S.; Kane, R. S. “Protein-assisted Solubilization of Single-Walled

Carbon Nanotubes”, Langmuir, 2006, 22, 1392.

34) Carrillo, A.; Yanjarappa, M.; Gujraty, K.; Kane, R. S. “Biofunctionalized Block Copolymer Nanoparticles Based on ROMP”,

Journal of Polymer Science Part A: Polymer Chemistry, 2006, 44, 928-939.

33) Yim, T.; Liu, J.; Lu, Y.; Kane, R. S.; Dordick, J. S. “Highly Active and Stable DNAzyme-Carbon Nanotube Hybrids”,

Journal of the American Chemical Society, 2005, 127, 12200.

32) Gujraty, K.; Sadacharan, S.; Frost, M.; Poon, V.; Kane, R. S.; Mogridge, J. “Functional Characterization of Peptide-based Anthrax

Toxin Inhibitors”, Molecular Pharmaceutics, 2005, 2, 367-372.

31) Carrillo, A.; Gujraty, K.; Rai, P.; Kane, R. S. “Design of Water-Soluble, Thiol-Reactive Polymers of Controlled Molecular Weight:

a Novel Multivalent Scaffold”, Nanotechnology, 2005, 16, S416-S421.

30) Koratkar, N.; Suhr, J.; Joshi, A.; Kane, R. S.; Schadler, L. S.; Ajayan, P. M.; Bartolucci, S. “Characterizing Energy Dissipation in

Single-walled Carbon Nanotube Composites”, Applied Physics Letters, 2005, 87, 6, #063102

29) Chakrapani, N.; Wei, B.; Carrillo, A.; Ajayan, P. M.; Kane, R. S. “Capillarity Driven Assembly of Two-dimensional Cellular Carbon

Nanotube Foams,” Proceedings of the National Academy of Sciences, USA, 2004, 101, 4009. Featured on the cover.

28) Karajanagi, S.; Vertegel, A.; Kane, R.S.; Dordick, J.S. “Structure and Function of Enzymes Adsorbed onto Single-Walled Carbon

Nanotubes,” Langmuir, 2004, 20, 11594.

27) Carrillo, A.; Kane, R. S. “Block Copolymer Nanoparticles of Controlled Size Via ROMP”, Journal of Polymer Science Part A:

Polymer Chemistry, 2004, 42, 3352.

26) Sethuraman, A.; Han, M.; Kane, R. S.; Belfort, G. “Effect of Surface Wettability on the Adhesion of Proteins,” Langmuir, 2004, 20, 7779.

25) Ashton, R.; Padala, C.; Kane, R. S. “Microfluidic Separation of DNA,” Current Opinion in Biotechnology, 2003, 14, 497 (invited contribution).

24) Carrillo, A.; Gujraty, K.; Kane, R. S. “Surfaces and Substrates” in Microarray Technology and its Applications, eds. D. Nicolau

and U. Muller, Springer-Verlag, New York, 2005.

23) Carrillo, A.; Swartz, J. A.; Gamba, J. M.; Kane, R. S.; Chakrapani, N.; Wei, B.; Ajayan, P. M. “Non-covalent Functionalization of

Graphite and Carbon Nanotubes with Polymer Multilayers and Gold Nanoparticles,” Nano Letters, 2003, 3, 1437.

22) Chakrapani, N.; Curran, S.; Wei, B.; Ajayan, P. M.; Carrillo, A.; Kane, R. S. “Spectral Fingerprinting of Structural Defects in Plasma Treated

Carbon Nanotubes,” Journal of Materials Research, 2003, 18, 2515.

21) Yim, T-J.; Kim, D-Y.; Karajanagi, S. S.; Lu, T-M.; Kane, R. S.; Dordick, J. S. “Si Nanocolumns as Novel Nanostructured Supports for

Enzyme Immobilization,” Journal of Nanoscience and Nanotechnology, 2003, 3, 479.

20) Ganesan, P. G.; Gamba, J.; Ellis, A.; Kane, R. S.; Ramanath, G. “Polyelectrolyte Nanolayers as Diffusion Barriers for Cu Metallization,”

Applied Physics Letters, 2003, 83, 16, 3302.

19) Ganesan, P. G.; Cui, G.; Ellis, A.; Kane, R. S.; Ramanath, G. “ Near-zero-thickness Self-assembled Molecular Layers for Future Device

Structures: Interfacial Adhesion and Diffusion Barrier Properties,” Materials Science Forum, 2004, 426-432, 3487.

18) Han, M.; Sethuraman, A.; Kane, R. S.; Belfort, G. “Nanometer-Scale Roughness has Little Effect on the Amount or Structural Stability

of Adsorbed Protein,” Langmuir, 2003, 19, 23, 9868.

17) Han, M.; Kane, R. S.; Goto, M.; Belfort, G. “Discriminate Surface Molecular Recognition Sites on a Microporous Substrate: A New Approach,”

Macromolecules, 2003, 36, 4472.

16) Mourez, M.; Kane, R. S.; Mogridge, J.; Metallo, S. M.; Deschatelets, P.; Sellman, B. R.; Whitesides, G. M.; Collier, J. “Designing a

Polyvalent Inhibitor of Anthrax Toxin,” Nature Biotechnology, 2001, 19, 958. Featured in Nature’s special online focus on bioterrorism.

15) Fuerstmann, M. J.; Deschatelets, P.; Kane, R. S.; Schwartz, A.; Kenis, P. J. A.; Deutch, J. M.; Whitesides, G. M. “Solving Mazes Using

Microfluidic Networks,” Langmuir, 2003, 19, 4714. Featured in Nature’s News and Views in Brief.

14) Kane, R. S.; Deschatelets, P.; Whitesides, G. M. “ Kosmotropes Form the Basis of Protein-Resistant Surfaces,” Langmuir, 2003, 19, 2388.

13) Stroock, A.; Kane, R. S.; Weck, M.; Metallo, S. J.; Whitesides, G. M. “Synthesis of Free-standing Quasi-Two-Dimensional Polymers,”

Langmuir, 2003, 19, 2466.

12) Metallo, S. M.; Kane, R. S.; Holmlin, R. E.; Whitesides, G. M. “Bifunctional Polymers Presenting Vancomycin and Fluorescein that Direct

Anti-Fluorescein Antibodies to Self assembled Monolayers Presenting D-Alanine-D-Alanine Groups,” Journal of the American Chemical Society,

2003, 125, 4534.

11) Kane, R. S., Jeon, N. L., Stroock, A., Ingber, D. E., Whitesides, G. M. “Microfluidics,” in Optical Biosensors, Eds. Ligler, Rowe-Taith, 571, 2002.

10) Kane, R. S., Glink, P. T., Chapman, R. G., McDonald, C., Jensen, P., Gao, H., Pasa-Tolic, L., Smith, R. D., Whitesides, G. M. “Study of

the Basicity of the Amino Groups of the Aminoglycoside Amikacin using Capillary Electrophoresis,” Analytical Chemistry, 2001, 73, 4028.

9) Chiu, D. T.; Jeon, N. L.; Huang, S.; Kane, R. S.; Wargo, C. J.; Choi, I. S.; Ingber, D. E.; Whitesides, G. M. “Patterned Deposition of Cells

and Proteins onto Surfaces by Using Three-dimensional Microfluidic Systems,” Proceedings of the National Academy of Sciences, USA,

2000, 97, 2408.

8) Ostuni, E.; Kane, R. S.; Chen, C. S.; Ingber, D.E.; Whitesides, G. M. “Patterning Mammalian Cells Using Elastomeric Membranes,”

Langmuir, 2000, 16, 7811.

7) Joly, S; Kane, R. S.; Radzilowski, L.; Wang, T.; Wu, A.; Cohen, R. E.; Thomas, E.L.; Rubner, M. F. “Multilayer Nanoreactors for

Metallic and Semiconducting Particles,” Langmuir, 2000, 16, 1354.

6) Kane, R. S.; Takayama, S.; Ostuni, E.; Ingber, D. E.; Whitesides, G. M. “Patterning Proteins and Cells Using Soft Lithography,” Biomaterials,

1999, 20, 2363. Featured in the Biomaterials Silver Jubilee Compendium as one of the 25 most significant papers published in

Biomaterials over the last 25 years

5) Takayama, S; Chapman, R. G.; Kane, R. S.; Whitesides, G. M. “Applications of Soft Lithography for Patterning of Cells and Their

Environment,” Book chapter in Principles of Tissue Engineering, 2nd Ed.; Ed: R. Lanza, R. Langer, J. Vacanti.

4) Kane, R. S.; Cohen, R. E.; Silbey, R. “Semiconductor Nanocluster Growth within Polymer Films,” Langmuir, 1999, 15, 39.

3) Kane, R.S.; Cohen, R. E.; Silbey, R. “Synthesis of Doped ZnS Nanoclusters within Block Copolymer Nanoreactors,”

Chemistry of Materials, 1999, 11, 90.

2) Kane, R. S.; Cohen, R. E.; Silbey, R. “Synthesis of PbS Nanoclusters within Block Copolymer Nanoreactors,” Chemistry of Materials, 1996, 8, 1919.

1) Kane, R. S.; Cohen, R. E.; Silbey, R. “Theoretical Study of the Electronic Structure of PbS Nanoclusters,” Journal of Physical Chemistry,

1996, 100, 7928.