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Currently, I'm interested in the development and analysis of mathematical models for physiological systems. One topic of study is mechanoperception, that is, the study of how a living organism senses and then recognizes mechanical stimuli. The mechanoreceptors that I'm presently working on are from the auditory system, cells in connective tissue, and tactile receptors.
The mechanisms through which skin transduces tactile stimuli from a mechanical to neural signal are not understood. Therefore, the goal of my research is to construct a mathematical model that describes this process. This project involves the study of the non-linear deformation of skin, the dynamics of the receptor system, and the nonlinear diffusion associated with the electro-chemical processes in the nerve. In this project I work very closely with neurophysiologists at the University of Syracuse.
Another of my research areas concerns modeling the biological tissues found in joints (such as the knee). The models are based on multiphasic continuum theories that realistically account for the multiple constituents found in tissue.
Introduction to Numerical Methods for Differential Equations, Springer-Verlag, 2006. Web page
Introduction to Perturbation Methods, Springer-Verlag, New York, 1995.
Mixture Theories for the Mechanics of Biological Tissues, RPI Web Book, 1995. Info Page
RTG coming soon (grant starts about Aug 15, 2007)
Guggenheim Fellow
Y.C. Fung Young Investigator Award (ASME)
2000 Premier Award for Excellence in Engineering Education Courseware
2001 ASME Curriculum Innovation Award
2002 Award for Innovative Excellence in Teaching, Learning and Technology
2002 Best Paper Award, 13th International Conference on College Teaching and Learning
2007 ICTCM Award for Excellence and Innovation with the Use of Technology in Collegiate Mathematics
2007 Rensselaer Trustee's Outstanding Teacher Award
"RTG: Research Training Group in Large-Scale Nonlinear Systems," with G. Kovacic, P. Kramer, Y. Lvov, and V. Roytburd, $1,272,000, National Science Foundation. Summary for first three years of grant.
"CSUMS: Computational Science Training in the Mathematical Sciences at Rensselaer," with I. Herron, G. Kovacic, P. Kramer, and V. Roytburd, $1,251,000, National Science Foundation. Summary for first three years of grant.
"Initiative for Vertical Integration of Research and Education in Applied Mathematics," with J. Flaherty, G. Kovacic, J. McLaughlin, and D. Schwendeman, $3,830,000, National Science Foundation. Summary for last two years of grant.
"Mathematics and its Applications in Engineering and Science: Building the Links," with W. Boyce, R. Spilker, K. Conner, and J. Wilson, $4,016,000, National Science Foundation.
Foundations of Applied Mathematics Fall '07
Intro to Math Research Spring '07
Slides for talk given in Math-6951 (Spring '07)
Calculus II Spring '06
Intro to the Numerical Solutions of Differential Equations Spring '05
Mac Resource Page Recommended software and recreational reading for Mac users.
New Toy Our new cluster.
Mailing Address:
Office: Amos Eaton 322
E-mail: holmes (@rpi.edu)
Phone: 518-276-6891
FAX: 518-276-2179