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Office: Science Center 3C44
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Office: Science Center 3C13
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Phone: 276-8442
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Phone: 276-6492
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office hours by arrangement
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office hours by arrangement
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Date and Time: Monday afternoons from 1-4 (immediately following the Biology Department seminar)
Location: Science Center 2C25
Text: Special Human Genome Issue (15 February 2001)
Science (http://www.sciencemag.org/feature/data/genomes/landmark.shl)and
Nature (http://www.nature.com/genomics/human/)plus additional selected articles
Proteomics.SR Pennington and MJ Dunn, ed.BIOS Scientific Publishing LTD.2001.
Class Format: Lecture to providebackground information plus discussion of topics based on assigned reading.All students are expected to read the selected references before class.
Assessment and Grading
Presentation.A group of students will lead the class discussion during selected weeks of the semester.Each student will be responsible for leading discussion twice during the semester – once during the genomics section and once during the proteomics section. Dates will be chosen by random allotment.
Summary and Analysis of discussion.Each week another group of students will be responsible for providing a written summary of the class discussion.Each student will be responsible for two written summaries during the semester – once during the genomics section and once during the proteomics section.Summaries are to be written individually and will be posted in webct.
Grade will be based on:
presentation
participation in class discussions
summary and analysis
Academic Integrity:Student-teacher relationships are built on trust.For example, students must trust that teachers have made appropriate decisions about the structure and content of the courses they teach, and teachers must trust that the work that students do is their own.Acts which violate this trust undermine the educational process.The Rensselaer Handbook defines various forms of academic dishonesty and procedures for responding to them.All forms are violations of the trust between students and teachers.Students should familiarize themselves with this portion of the Handbook and should note that the penalties for plagiarism and other forms of cheating are quite harsh.
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Schedule
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Part 1 – Genomics: Dr. Donna E.Crone
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Aug 27
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Introduction to the Human Genome Project
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Sept 3-
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No Class Labor Day
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Sept 10
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Physical Mapping and Sequencing of the genome
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Sept 17
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Sequence Analysis and Annotation
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Sept 24
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Sequence Analysis:comparative
homologies, Evolutionary changes and Single Nucleotide Polymorphisms
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Oct 1
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Expression: analysis of expressed genes
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Oct 9 (Tues= Mon)
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Epigenetics: control of gene expression and how
itsaffects proteins that are
present in cell at any one time
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Oct 15
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Post Genomics..
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Part 2 – Proteomics: Dr. Jane F. Koretz
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Oct 22
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Dr.Donita Garland, Chief, Protein Biochemistry Section
Laboratory of Molecular and Developmental Biology National Eye Institute topic:What is PROTEOMICS? Overview:systems, time course, info, databases, post-translational modification, etc. |
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Oct 29
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2-Dimensional gel electrophoresis
-Methods (including IPGs), -Resolution -Reproducibility and image analysis -Future developments |
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Nov 5
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Mass spectroscopy
-Methods/strategies -Protein identification -De novo protein characterization -Isotope labeling -N- and C-terminal tags |
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Nov 12
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Other methods I
-Co- and post-translational modification -Automation -Creating and using the databases |
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Nov 19
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NO CLASS
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Nov 26
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Other methods II
-Microarrays -Phage anitbodies -Integrating proteomics and bioinformatics |
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Dec 3(last day of classes 12/7)
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Biological and biomedical applications
-Drug discovery -Diagnosis and treatment -Etc. |
last updated 8/25/01