COURSE DESCRIPTION: Students will learn about organization of prokaryotic and eukaryotic genomes, the molecular tools and techniques for studying genomes, basic molecular processes in cells and organisms. The emphasis of this course will be on the control of gene expression from the level of the chromosome to the translation of the gene transcript. The applications of sequenced genomes to basic scientific research as well as medical and forensic studies will be discussed.

LEARNING OUTCOMES:
At the end of the course a successful student will be able to:
Understand and use proper scientific vocabulary to communicate information in molecular biology.
Demonstrate knowledge of the structures, properties and biological significance of the major classes of molecules found in living organisms and the relationship between molecular structure and biological function
Demonstrate a thorough understanding of the basic principles of molecular biology including:

• Central dogma
• Structure, organization and packaging of eukaryotic, prokaryotic and viral genomes
• Mobile genetic elements and repetitive sequences
• Events involved in initiation, elongation, termination and processing of RNA and protein and their regulation
• Functional RNA and its role in gene expression
• Regulation of genome activity
• DNA replication, mutation, recombination     

Compare and contrast major features of transcription, translation and replication in prokaryotic and eukaryotic organisms
Describe molecular tools and techniques used in the study of DNA and in the annotation of sequenced genomes

ASSESSMENT
Homework (20%).  A few multiple choice questions are assigned corresponding to almost every lecture as noted on syllabus.  These are done in webCT and are due before the next class.  Late HW will be accepted with a late penalty.
In-class Exams (60%).  Four in-class exams will be given on the dates noted in the schedule. The lowest score of the four will be dropped.  Make-up exams will be scheduled for students with valid medical reasons for missing the original exam. An exam missed without an excuse will be counted as a zero and will be included among the three hour exams used to determine your grade.
Final exam (20%).  Comprehensive final exam is required for all students.  

Final grades are determined from the percent of total point accumulated.

ACADEMIC DISHONESTY
Anyone found cheating on an exam will be given an F for that exam.  No books, notes, crib sheets or other written material can be used during an exam.  Looking at another student's paper is not permitted.  Anyone giving or receiving assistance during an exam will be considered cheating.  Any exams handed back to the instructor for regrading should have no additional marks on the exam.  Anyone altering an exam for the purpose of regrading will be given an F for the course grade.
Students who violate the spirit or letter of these rules are subject to penalties according to the principles outlined in the Rensselaer Handbook.

Tentative Schedule (any revisions to the schedule posted will be posted in webCT/ RPI LMS)

Please note that March 6 is the last day for students to drop courses without appeal.