ANGEL E. GARCIA
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Title(s): | Sr. Constellation Chair Biocomputaion & Bioinformatics | ||
| Professor | ||||
| Department: | Department of Physics, Applied Physics and Astronomy | |||
| Email: | angel@rpi.edu | |||
| Phone: | (518) 276-4206 | |||
| Fax: | (518) 276-6680 | |||
| Postal Mail: | Rensselaer Polytechnic Institute, 110-8th Street | |||
| (3244C Biotechnology Bldg.) Troy, NY 12180 USA |
Career Highlights
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García received a bachelor's and master's degree from the University of Puerto Rico and a doctorate in physics from Cornell University. He is a fellow of the American Physical Society and a member of the Biophysical Society and the American Chemical Society. He is a past elected executive board member of the American Physical Society's Division of Biological Physics; an executive committee member of the Center for Non-Linear Studies at Los Alamos National Laboratory; and a scientific board member of the Institute for Complex Adaptive Matter at the University of California. García is a member of the editorial board of Biophysical Journal and Molecular Simulations and a member of the Faculty of 1000 for BioMed Central, an online research service that reviews the most interesting papers published in the biological sciences, based on the recommendations of a faculty of more than 1,000 selected leading researchers. He is also a past member of the scientific review committee for the National Institutes of Health (NIH) and the National Science Foundation (NSF). |
Research Areas
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Professor Garcia's research interests span mathematical modeling and computational analysis of problems in cellular and molecular biology as well as theoretical and computational aspects of biomolecular dynamics. |
Selected Publications
- D. Paschek, S. Gnanakaran, and A.E. Garcia, “Simulations of the Pressure and Temperature Unfolding of an Alpha Helical Peptide,” Proc. Natl. Acad. Sci. (USA) 102: 6765-6770 (2005)
- D. Paschek and A.E. Garcia, “Reversible temperature and pressure denaturation of a protein fragment: Replica exchange molecular dynamics simulation study,” Phys. Rev. Let. 93, 238105 (2004)
- S. Gnanakaran, Robin M. Hochstrasser and Angel E. García. “Nature of structural inhomogeneities on folding a helix and their influence on spectral measurements,” Proc. Natl. Acad. Sci. 101: 9229-9234 (2004).
- A.E. Garcia and J.N. Onuchic, "Folding a protein in a computer; an atomic description of the folding/unfolding of protein A., " Proc. Natl. Acad. Sci. 100: 13898-13903 (2003).
- M.S. Cheung and A.E. Garcia and J. N. Onuchic, “Protein folding mediated by solvation: water expelling and formation of the hydrophobic core occur after the structural collapse,'' Proc. Natl. Acad. Sci. (USA) 99: 685-690 (2002)
- A.E. Garcia and K.Y. Sanbonmatsu, "Alpha helical stabilization by side chain shielding of backbone hydrogen bonds," Proc. Natl. Acad. Sci. (USA) 99: 2782-2787 (2002)
- A.E. Garcia and K.S. Sanbonmatsu, ''Exploring the Energy Landscape of a beta hairpin in explicit solvent," Proteins, Str. Funct. & Genet. 42: 345-354 (2001)
- G. Hummmer, S. Garde, A.E. Garcia and L.R. Pratt, “New Perspectives on Hydrophobic Effect, Chem. Phys. 258: 349-370 (2000)
- H. Nymeyer, A.E. Garcia and J.N. Onuchic, “Folding Funnels and Frustration in Off-Lattice Minimalist Protein Landscapes," Proc. Natl. Acad. Sci. (USA), 95: 5921-5928 (1998)
- G. Hummer, S. Garde, A.E. Garcia, M. Paulaitis and L.R. Pratt, “The Pressure Dependence of Hydrophobic Interactions is Consistent with the Observed Pressure Denaturation of Proteins," Proc. Natl. Acad. Sci. 95: 1552—1555 (1998)
- G. Hummer, S. Garde, A.E. Garcia, A. Pohorille, and L.R. Pratt, “A Heuristic Molecular Model of Hydrophobic Interactions," Proc. Natl. Acad. Sci. 93: 8951-8955 (1996)
- A.E. Garcia, “Large-Amplitude Non-Linear Motions in Proteins," Phys. Rev. Lett. 68: 2696-2700 (1992)
Professional Appointments
| 2005-present | Senior Constellation Professor for Biocomputation and Bioinformatics, Rensselaer Polytechnic Institute, Troy, NY | |
| 2001-2005 | Group Leader, Theoretical Biology and Biophysics Group Theoretical Division, Los Alamos National Laboratory (LANL), Los Alamos, NM | |
| 1989-2005 | Staff Member, Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory Los Alamos, NM |
Professional Preparation
| Cornell University | Theoretical Physics | Ph.D. 1987 | ||
| University of Puerto Rico | Physics | M.S. 1981 | ||
| University of Puerto Rico | Physics | B.S. 1978 | ||
| (Magna Cum Laude) |
