DNAzyme-Catalyzed Assembly and Sensing

Genetic control of stimuli-response assembly and disassembly of nanoparticles and carbon nanotubes at ambient conditions has been demonstrated using analyte-specific DNAzymes (Lu). For chemical sensing, DNAzyme-nanoparticle hybrids have been transformed into simple, highly sensitive and selective colorimetric sensors for a broad range of analytes including metal ions and organic molecules, with tunable detection range. This has application in sensor development. For example, the ability of lead to dissociate DNAzyme-nanoparticle hybrids under ambient conditions and over a wide range of lead concentrations can be used to quantify the level of lead in paints, which has key consequences in low-income housing and older units in urban areas. This technology is being commercialized by DzymeTech, a start-up venture founded through NSEC technology.