Class:
Chromatographic Separation Processes, CHME 4400 and CHME 6967
Meets Monday and Thursday in Ricketts 211 from 12:00-1:50 PM 

Instructor:
Steven M. Cramer, Professor of Chemical and Biological Engineering
3211 Biotech. Bldg., Ext. 6198, email: crames@rpi.edu
Office hours (Fridays @ 11am-1pm in the Coonly Lounge, Ricketts Building)

Teaching Assistant:
Chris J. Morrison
3215 Biotech. Bldg., Ext. 4276, email: morric2@rpi.edu 
Office hours (Tuesdays @ 2-4pm in the Coonly Loung, Ricketts Building)
 

Course Outline:
This is an interdisciplinary course suitable for graduate students and qualified seniors in Chemical and Biological Engineering, Chemistry, Biology, and Biomedical Engineering.  The objective of this course is to familiarize the student with the theory and practice of the state of the art of analytical and preparative chromatographic separation processes. Topics include: general concepts (e.g.  dynamics of zone migration, multicomponent adsorption, chromatographic dispersion, linear and non-linear chromatography); liquid chromatographic techniques (e.g. reversed-phase, ion exchange, affinity, chiral, metal chelate, and size exclusion); modes of operation (e.g. gradient, preparative elution, displacement, and continuous chromatography); novel morphologies and materials (e.g. annular, radial flow, perfusion, and membrane and monolith chromatography) and considerations and insights for chromatographic biomanufacturing at the industrial scale. Critical reviews of the current literature will be carried out to expose the students to the latest developments in the field.  Laboratory demonstrations as well as computer simulations will be employed throughout the course to illustrate important concepts.  An individual project on a chromatographic topic of interest will be required for all graduate students and will be optional (i.e. extra credit) for undergraduates. 

Course Materials:
No Text is required for this course.  A variety of reference books and research papers will be used in the course and extensive handouts will be given on all topics. 

Student Work:
- Students taking 32-4400: Weekly homework assignments (20%),  Mid-term (35%) and final exam (45%). (note: undergraduate students can obtain extra credit by doing an individual project).
- Students taking 32-6964:  Weekly homework assignments (15%), Oral and written presentations on special topic reports (25%), Mid-term (25%) and final exam (35%). 

Laboratory Demonstrations:
There will be laboratory demonstrations to help illustrate the chromatographic concepts presented in the lectures. 

Computer Simulations:
Computer simulations will be employed to simulate Displacement Chromatography, Gradient Chromatography and Multi-step Downstream Bioprocessing to gain insight into these state-of-the-art technologies and to instruct the student how to optimize sequential chromatographic separations for the downstream processing of biopharmaceuticals. 

Coursework Online:

Lecture Notes

Assignments

Handouts

Last update: 2007/01/18 10:14:43