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Fundamentals
of Protein Adsorption in Mixed Mode Chromatographic Systems (with Garde, Breneman, McCallum and Lakshmi): Fundamental studies of protein
affinity in ion exchange and mixed mode chromatographic systems using state
of the art experimental (NMR, SPR, EPR, high throughput screening), chemometrics and molecular modeling techniques.
Applications for purification of complex biological mixtures for
biopharmaceutical applications. Fundamentals
of Protein Adsorption in Hydroxyapatite Chromatographic Systems: Fundamental studies of protein affinity in
hydroxyapatite chromatographic systems using state of the art experimental chemometrics and molecular modeling techniques.
Applications for purification of antibodies and aggregate removal. Selective
Displacement Chromatography of Proteins in Ion Exchange and Mixed Mode
Systems (with Moore): Design of selective low molecular
weight displacers for protein purification in ion exchange and mixed mode
systems. Purification of complex biological mixtures and investigation of the
relationship between displacer chemistry and efficacy in various classes of
chromatographic materials. Chip Based
Bioseparations Systems (with
Plawsky):
Investigate the utility of novel microscale
chromatographic systems on chips for a variety of applications in combinatorics and proteomics. Also, development of dielectrophoresis based separations for protein
separations. Multidimensional Proteomics Platform (with Platt and Plopper): Employ ion exchange displacement
chromatography, nano-flow RPLC and state-of-the-art
mass spectrometry (MS) to develop a powerful proteomics analysis platform for
the protein profiling of human mesenchymal stem
cells. Smart Biopolymer Affinity Precipitation
Systems (with Chen,
UCR): Development of an ELP based
smart biopolymer fusion protein affinity precipitation reagent systems.
Applications for purification of antibodies and new classes of
biopharmaceuticals. Chemometric
Approaches for Fault Detection in Large Scale Chromatography (with Shukla): Development of chemometric
based analyses of transitions in large scale chromatographic data for fault
detection and yield predictions.
Last update: 02/18/02 |
