Henry R. Bungay

High-rate Continuous Culture

Maintaining high nutrient concentration in continuous culture of microorganisms creates intense competition for organisms to divide to prevent washout from the system. After a few days, the nutrients are being pumped in so rapidly that the organisms divide in less than eight minutes, and only very rapidly dividing organisms are present. This technique permits research on extremely dynamic metabolism and has practical value for the high-rate propagators or for producing biochemicals associated with logarithmic growth phase. We are using similar approaches for very rapid conversion of waste paper to cellular protein and to organic chemicals. Another project is resolution of mixtures because the microorganisms use the easy substrates and leave the more difficultly metabolized nutrients enriched for easier recovery.

Link to pH auxostats

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Last update: 27-Feb-96