The Biomolecular Separations Research Group conducts research on fundamental and applied aspects of separations processes in biochemical engineering. Interactions of proteins with substrates especially polymeric surfaces such as synthetic membranes, chromatographic media, marine surfaces, and biomedical surfaces (catheters) are measured to obtain adhesive forces. How surfaces of different chemistry influence protein secondary structure is also being determined.

A comprehensive research program on modifying polymeric surfaces using wet chemistry, low temperature plasma and photo-induced graft polymerization has been pursued to obtain surfaces that exhibit specific desirable properties (i.e., low protein adhesion, high specific binding, etc...).

Another focus of the group is to recover desirable proteins from biologically-derived solutions and suspensions. Methods such as fusion affinity adsorption, pressure-driven membrane processes and expanded-bed adsorption are being evaluated.

We are also modifying membrane surfaces for recovery drinking water that exhibit reduced natural organic matter fouling during filtration.

In summary, we attempt to use fundamental concepts for solving applied problems in the biological and environmental fields.

Copyright © 2003 Georges Belfort, Rensselaer Polytechnic Institute