Belfort Group

Biomolecular Separations Reseach Group.
Howard P. Isermann Department of Chemical and Biological Engineering
and Center for Biotechnology and Interdisciplinary Studies
Rensselaer Polytechnic Institute
Troy, NY 12180, USA


The Belfort group has a long tradition of collaborating with other scientists and engineers; Currently, these include:

Dr. Marlene Belfort, Distinguished Professor, Department of Biological Sciences, University at Albany, State University of New York, Albany, NY; Collaboration with the M. Belfort lab. focuses on the use of genetic techniques to recover desirable proteins from cell lysate using inteins in one step in a laboratory and fluidics platform, elucidating the mechanism of protein cleavage to discover inhibitors of inteins to stop tuberculosis and designing and test antibody and aptamer sensors based on intein technology.

Dr. Brian Chait, Professor, Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, Rockefeller University, NY City, NY: Understanding the dynamic behavior of the nuclear pore complex during transport is the basis of this collaboration.

Dr. Payal Das, Research Staff Member - molecular modeling and simulation, Thomas J. Watson Research Center, Yorktown Heights, NY: Molecular simulations of Abeta variants and Abeta wild type with chaperone proteins like alpha B crystallin

Dr. Shekhar Garde, Assistant Professor, Department of Chemical and Biological Engineering, RPI: Molecular modeling to elucidate the fluctuation behavior of water near different a-polar and polar surfaces.

Dr John Katsaras, Senior Scientist Biologiacl Systems, and Dr. Robert Standaert, Oak Ridge National Laboratory: Neutron scattering analysis of the conversion of amyloidogenic proteins: structure and kinetics.

Dr. Chip Kilduff, Associate Professor, Department of Civil & Environmental Engineering, RPI; Collaboration involves the development of new surface-modified synthetic filtration membranes for domestic treatment of surface waters using photo- and plasma-induced graft polymerization and development of new membranes.

Dr. Jan Kmetko, Assisant Professor, Kenyon College Physics Department, Gambier, Ohio; Conducts neutron reflectometry measurements and theory on lipid bilayers with the Belfort Group.

Dr. Nikhil Koratkar, Crossan Endowed Chair Professor, Mechanical Engineering Department, RPI; Develop filtration membranes with graphene oxide.

Dr. Sanat K. Kumar, Professor of Chemical Engineering, Department Head, Chemical Engineering Department Columbia University, New York, NY; Model the interaction of proteins with surface using Lattice Modeling.

Dr. Robert Langer, Koch Professor, and Dr. Dan Anderson, Associate Professor, Department of Chemical Engineering and Health Sciences & Technology, MIT, Cambridge, MA; Collaboration involves the functionalization of polymeric surfaces to produce environmentally responsive surfaces and investigating water structure near surfaces using Sum Frequency Generation spectroscopy.

Dr. Igor Lednev, Assistant Professor, Department of Chemistry, University at Albany, State University of New York, Albany, NY: Deep UV spectroscopy of amyloid oligomers to determine secondary structure.

Dr. Scott Manalis, Professor, Department of Biological and Mechanical Engineering MIT, Cambridge, MA; Develping an Abeta sensor using acoustic vibrations

Dr. Li Niu, Head, Deparment of Cheimisty UAlbany, Collaborates with the Belfort Group on transport through NMDAR receptors and the interference of Abeta peptide variants.

Dr. Michael Rout, Professor, and Dr. Ryo Hayama,Post-doctoral Associate, Laboratory of Cellular and Structural Biology, Rockefeller University, NY City, NY; Understanding the dynamic behavior of the nuclear pore complex during transport is the basis of this collaboration.

Dr. Sally Temple, Professor, Albany Medical College; Director, New York State Stem Cell Institute, Rensselaer, NY: Interaction between abeta and chaperone proteins like alpha B crystalline and RPE cells.

Dr. Jianjun Wang, Department of Biochemistry and Molecular Biology Wayne state Univerisity, NMR specialist focusing on the structure of ApoE variants and their binding to Abeta1-42 variants .

Dr. K. Dane Wittrup, C.P. Dubbs Professor, Department of Chemical Engineering and Biological Engineering MIT, Cambridge, MA; development of antibodies against Abeta amyloid conformers for the Belfort Group sensor work.

Dr. Yubing Xie, Assistant Professor, School for Nanoscience and Nanoengineering, Albany, NY; Matrix development for non-differentiating stem cells.

Dr. Y. Elaine Zhu, Assistant Professor, Department of Chemical and Bimolecular Engineering, University of Notre Dame; Fluorescence Correlation Spectroscopy analysis of the conversion of amyloidogenic proteins: structure and kinetics.