The product can be purified by chromatography but tends to isomerize to a molecule with improper folding that induces unacceptable side reactions. As with other peptides, purification by crystalliztion is possible but difficult. Our people have been the first to cyrstallize this polypeptide and have pending patents on the best buffers.
Only our people have obtained crystals from heavily supersaturated solutions (more like colloidal suspensions than true solutions) and have overcome the tendency to form a viscous glop. Your assignment is to develop a crystallization process.
Nothing happens unless the concentration is greater than the solubility. When only slightly supersaturated, crystals may not form unles seed crystals are added. The growth rate depends on the driving force. When greatly supersaturated, the high driving force can induce rapid deposition that risks having foreign ions or molecules as part of the crystal because of insufficient time for the correct species to reach its spot in the lattice.