Theory of fed-batch fermentation
Fed-batch fermentation is described in BASIC Biochemical Engineering
(Bungay, 1993) as the type of system where "nutrient is added when
its concentration falls below some set point." Usually the addition is of the
nutrient is controlled by a computer for precision. The best way to control
the addition of the feed is to monitor the concentration of the nutrient itself
in the fermenter or reactor vessel, so you know exactly how much more of it
needs to be added.
The nutrient is added in several doses, to ensure that there is not too much of
the nutrient present in the fermenter at any time. If too much of a nutrient
is present, it may inhibit the growth of the cells. By adding the nutrient a
little bit at the time, the reaction can proceed at a high rate of production
without getting overloaded.
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Written by Kurt M. Fritzsche (fritzk@rpi.edu)
, 7-December-1995.
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Last update: 7 December 1995