Ethanol Auxostat

An ethanol-auxostat was operated in an acetic acid bioprocess using an organic vapor sensor (Mü hlemann and Bungay, 1993). Ethanol concentration in a bioreactor was held constant by using the signal from a commercial gas-sensor for organic vapors. Gas-sensors for alarm systems are very inexpensive and are suitable for organic nutrients that are volatile. Unlike an electrode, a gas-sensor is electrically insulated from the liquid environment and is unlikely to become fouled. Substrate concentration in the gas phase above the broth should be in dynamic equilibrium with the liquid phase.

This gas-sensor consists of a sensing element and a heater. The small sensing element is SnO2 sintered metal. When heated to about 400 C with no oxygen present, free electrons flow easily through the grain boundary of the tin dioxide SnO2 particles. Oxygen adsorbed on the particle surface forms a potential barrier in the grain boundaries that traps free electrons. This restricts their flow, causing the electrical resistance to increase. When the sensor element adsorbs reducing gases, their oxidation lowers the potential barrier, allowing electrons to flow more easily, thereby reducing the electric resistance.

The sensor mounted in the fermenter head space can be seen in the next figure. The unit in a rubber stopper fits into the fermenter lid. Air from the head space flows through the flame arrester to the sensing element. To get renewal around the sensing element, gas is allowed to escape through the back of the sensor. A stainless steel grid shaped as a cone prevents splashing from reaching the sensor.

For aseptic operation, the electrode should be mounted in the exit gas line. The additional lag time would be small. Calibration of the whole system links the ethanol concentration in the broth with the sensor output voltage. Air stripping of ethanol from the culture fluid was measured and could be reconciled in mass balances.

An acetic acid bioprocess was the model for evaluating the ethanol auxostat. Ethanol was the growth-limiting substrate. Soil was the inoculum. The auxostat principle was demonstrated by runs of several hundred hours. All bioreactors were open, and only the feed was sterile. Use "BACK" to go with the flow.

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