David Heine, Ph.D.

Senior Research Scientist
Corning Incorporated

Presentation

Multiscale Modeling of Lipid Bilayer Interactions with Solid Substrates

In an in-vitro environment, lipid bilayers immobilized on organic or inorganic surfaces serve as the scaffold for transmembrane protein receptors, which in turn are the targets of most therapeutic drugs. Further, understanding the interaction mechanism between nanoparticles and lipid membranes is critical for designing microplates for drug screening as well as understanding the cytotoxicity of nanomaterials and the mechanism of viral infection.

This talk presents a multiscale modeling approach to study the behavior of lipid bilayers on silica substrates. We apply fully atomistic molecular dynamics simulations of lipid bilayers on silica substrates to identify the influence of the substrate on the bilayer structure and dynamics. These parameters are incorporated into a coarse-grained model of a bilayer on rough substrates and nanoparticle-coated substrates to determine the impact of surface topography on membrane behavior. The results are compared to force measurements between the bilayer and bare substrate using the Surface Forces Apparatus and atomic force microscopy measurements of bilayers on nanoparticle-coated substrates.

Biography

David Heine earned his Ph.D. in Chemical Engineering at the Colorado School of Mines in 2001. Prior to joining Corning, he was a post-doctoral fellow for three years at Sandia National Laboratories in Albuquerque where he studied surface wetting and polymer network formation. He is currently a senior research scientist at Corning specializing in materials modeling in support of a variety of Corning's businesses.

updated: 2008-09-16