Angel Garcia, Ph.D.

Senior Constellation Professor of Biocomputation And Bioinformatics
Rensselaer Polytechnic Institute


Theoretical and Computational Models of Biomolecular Dynamics and Function

We use molecular dynamics simulations to study the folding of proteins and nucleic acids. The protein folding problem has been one of the major challenges in computational biology. Currently, we can model the complete process of protein folding in full atomic detail for protein for fast folding, alpha helical proteins. From these simulations we can study the relative importance of competing interactions in determining the thermodynamic stability of proteins. We also study how external parameters, like temperature and pressure, and co-solvents can affect protein stability.


Dr. Garcia is the Senior Constellation Professor of Biocomputation and Bioinformatics at Rensselaer. Before joining Rensselaer he was Group Leader at the Theoretical Biology and Biophysics Group at Los Alamos National Laboratory. Dr Garcia is a Fellow of the American Physical Society. He received the Edward Bouchet Award from the American Physical Society in 2006. Dr. Garcia is the Associate Editor of Proteins, Structure, Function and Bioinformatics and belongs to the editorial board of Biophysical Journal and Molecular Simulations. He is a member of the American Physical Society, Biophysical Society, American Chemical Society, Protein Society and the American Association for the Advancement of Science.

updated: 2008-09-18