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| Biomedical Engineering (School of Engineering) |
| BMED-2200 Dynamic Systems for Biomedical Engineering Introduction of the modeling, analysis, and control of dynamic systems. Models of electrical, mechanical, electromechanical, and mass-transport systems in state-variable, input-output, and transfer function form. Linear approximations of nonlinear systems. Time domain and Laplace transform solutions, Block diagrams, and feedback systems. Solutions using a standard software package with graphic user interface. Corequisites: MATH-2400, PHYS-1200. Spring term annually. 4 credit hours |
| BMED-2940 Studies in Biomedical Engineering Each term. 1 to 4 credit hours |
| BMED-2960 Topics in Biomedical Engineering Each term. 1 to 4 credit hours |
| BMED-4010 Biomedical Engineering Laboratory Theory and practice of biomedical measurements. An introduction to instruments and procedures for measurement of pressure, flow, bioelectrical potentials, biomechanical and biomaterial properties, using invasive and noninvasive techniques. Transducers studied include strain gauge, differential transformer, spectrometer, blood gas electrodes, bipotential electrodes, microscope with camera, mechanical testing machine, piezoelectric transducer (or sensor), radioisotope detector. Also studied are instruments for determination of material properties. Includes in vivo use of invasive instruments. Prerequisites: BMED-2200, BMED-4500 or permission of instructor. Fall term annually. 4 credit hours |
| BMED-4240 Tissue-Biomaterial Interactions Relationships between structure and properties of synthetic implant materials, including metals, polymers, ceramics, and composites. The emphasis is on mechanical, corrosion, and surface properties of materials. An introduction to biocompatibility with special emphasis on the interaction of biomaterials with cells and tissues. Detailed review of blood-material interactions. Case studies of implants are discussed to illustrate biomaterials selection as a key part of implant design. Prerequisites: ENGR-1600, BIOL-4290, or permission of instructor. Spring term annually. 4 credit hours |
| BMED-4470 Signals and Images Principles of computer-based signal processing and imaging, covering the theoretical basis and practical applications. Topics include acquiring biomedical images, image correction and enhancement, signal and image processing, and 3-D images. Applications are to tomographic imaging, ultrasound, and microscopy. Prerequisite: BMED-2200. Spring semester, even-numbered years. 4 credit hours |
| BMED-4490 Sensors and Instruments The engineering science that gives rise to the successful performance of medical instruments when they are connected to living systems. The physical and chemical laws that are applied to sensing, actuating, and control functions in medical devices. Models and designs are discussed in terms of optimum use of fundamental relationships, accommodating fundamental constraints, and meeting medical requirements. Consideration is given to identifying the role of instrument design in the diagnosis of diseases and the therapy to treat those diseases. Prerequisite: ECSE-2410. Spring term, odd-numbered years. 4 credit hours |
| BMED-4500 Advanced Systems Physiology Applications of control theory and systems techniques to physiology. Emphasis is on entire systems and their interactions rather than isolated phenomena. Areas covered include cardiac, respiratory, renal, and gastrointestinal systems. Includes laboratory on the application of engineering techniques in the study of physiological systems. Prerequisite: BIOL-4290 or equivalent. Spring term annually. 4 credit hours |
| BMED-4540 Biomechanics Application of mechanics to the study of normal, diseased, and traumatized musculo-skeletal system. Areas covered include determination of joint and muscle forces, mechanical properties of biological tissues, and structural analysis of bone-implant systems. Case studies are discussed to illustrate the role of biomechanics and biomaterials in the design of implants. Prerequisite: ENGR-2050, corequisite: BMED-2200. Fall term annually. 4 credit hours |
| BMED-4600 Biomedical Engineering Design A guided approach to development of design skills. Students work individually and in teams to tackle a biomedical design problem using methods drawn as necessary from engineering and from the physical and mathematical sciences. Discussion sessions involve students in presentations of work. This is a writing-intensive course. Prerequisite: senior standing. Spring term annually. 3 credit hours |
| BMED-4650 Introduction to Cell and Tissue Engineering This course teaches the use of engineering principles to describe cellular processes of biological, chemical, and physical nature. A quantitative approach will be used to explain the behavior of cells under various physical stimuli through the application of the laws of physics, mathematics, and physical biochemistry. The transduction of these physical stimuli into modified behavior and their impact on organ level performance/function and tissue engineering will be discussed in the case of mammalian cells. Prerequisite: A basic course in mechanics (ENGR-2530 or BMED-4540, and a basic course in transport phenomena or fluid dynamics (ENGR- 2250 or equivalent), or permission of instructor. Fall semester annually. 3 credit hours |
| BMED-4940 Studies in Biomedical Engineering Each term. 1 to 4 credit hours |
| BMED-4960 Topics in Biomedical Engineering Each term. 1 to 4 credit hours |
| BMED-6240 Tissue-Implant Interfaces An examination of biomaterial and biomechanical factors affecting events at tissue-implant interfaces, with emphasis on biomaterial surface properties plus cell and molecular interactions. Prerequisites: BIOL-4290 and BMED-4500 or permission of instructor. Fall term annually. 3 credit hours |
| BMED-6280 Biomechanics of Soft Tissues Application of continuum mechanics in modeling the biomechanical behavior of nonmineralized tissues such as tendons, ligaments, skin, cartilage, blood vessels, etc. Topics include structure of collagen, elastin proteoglycans, and other tissue components, nonlinear elastic models (including Fung’s pseudoelasticity approach and strain energy functions), linear viscoelasticity, Fung’s quasilinear viscoelasticity, hereditary integral formulation of constitutive equations, and introduction to mixture theory. Fall term odd-numbered years. 3 credit hours |
| BMED-6290 Biomechanics of Hard Tissues Structure-property relationships for mineralized connective tissues of the human body. Discussion centers on various types of bone (e.g., lamellar, woven) and teeth with an emphasis on models for biomechanical behavior, both in vitro and in vivo. Topics include elastic models for bone (isotropic and anisotropic), theories of yielding and fatigue, strength properties, composite and hierarchical models, and models of bone remodeling/modeling. Fall term even-numbered years. 3 credit hours |
| BMED-6350 Fluid Dynamics and Transport in the Vascular Circulation The principles of convective diffusion in liquids are discussed as applied to the vascular circulation. Topics include: convective and diffusion boundary layers in internal flows with reacting and/or permeable walls, Taylor dispersion, microhydrodynamics of macromolecules and particles, Brownian motion, mass transport to arterial walls and across cell membranes. This course is intended for first year graduate students in Biomedical Engineering and undergraduate seniors with permission of the instructor. Spring term, even-numbered years. 3 credit hours |
| BMED-6480 Adaptive Systems This course contains the fundamental theory required to design adaptive systems. Topics include parameter identification, ARMA modeling, model reference systems, model algorithmic control, self-tuning systems, and adaptive filtering. Applications to physical and physiological systems are introduced. (Cross listed as ECSE-6480). Prerequisite: ECSE-6400 or equivalent. Spring term odd- numbered years. 3 credit hours |
| BMED-6500 Mechanobiology Mechanical regulation of biological systems will be discussed. Topics include principles and concepts of mechanobiology; embryogenesis and histogenesis of tissues with particular references to skeletal system; physical forces at cellular, tissue and organ level; mechanical regulation of cellular behavior, tissue growth, and organ development; limits of mechanical regulation; biochemical influences; application of mechanobiology to tissue regeneration. Prerequisites: BMED-4540 or ENGR-2530 with permission from the instructor. Graduate Course; spring semester. 3 credit hours |
| BMED-6550 Cell Biomechanics The mechanics of single cells and cells in a continuum are discussed in the context of the modulation of cell function by mechanical stresses. Topics include: mechanical forces in the natural environment of various mammalian cells (erythrocytes, leukocytes, osteoblasts, and epithelial cells), mathematical formulations of force distribution and force transmission, cell motility, models of cell membrane skeleton, cell deformability and elasticity, mechanical properties of cell membranes, and role of mechanical forces in cell structure/function. Prerequisites: BMED-4540 or ENGR-2530 with permission from the instructor. Spring alternate years. 3 credit hours |
| BMED-6940 Studies in Biomedical Engineering Each term. 1 to 4 credit hours |
| BMED-6960 Topics in Biomedical Engineering New courses or special course offerings are given under this number from time to time. Graduate students in biomedical engineering may pursue special interests under this number when sponsored by a biomedical engineering faculty member and with the permission of the department. Offered by individual arrangement. 1 to 4 credit hours |
| BMED-6980 Master’s Project Active participation in a master’s-level project under the supervision of a faculty adviser, leading to a master’s project report. Grades of IP are assigned until the master’s project has been approved by the faculty adviser. If recommended by the adviser, the Master’s Project may be accepted by the Office of Graduate Education to be archived in the Library. Grades will then be listed as S. 3 to 6 credit hours |
| BMED-6990 Master’s Thesis Active participation in research, under the supervision of a faculty adviser, leading to a master’s thesis. Grades of IP are assigned until the thesis has been approved by the faculty adviser and accepted by the Office of Graduate Education to be archived in a standard format in the library. Grades will then be listed as S. 6 to 9 credit hours |
| BMED-9990 Dissertation Active participation in research, under the supervision of a faculty adviser, leading to a doctoral dissertation. Grades of IP are assigned until the dissertation has been publicly defended, approved by the doctoral committee, and accepted by the Office of Graduate Education to be archived in a standard format in the library. Grades will then be listed as S. Variable credit hours |
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Rensselaer Polytechnic Institute (RPI), 110 8th St., Troy, NY 12180. (518) 276-6000 Please direct questions regarding this site to catalog@rpi.edu. |