and Cellular Bioengineering
My laboratory investigates the fundamental aspects of fluid mechanics
and mass transport that are involved in the modulation of mammalian
cell function. Special attention is given to the cells in the arterial
circulation with major research efforts directed to identify the
mechanistic links between hemodynamics and vascular biology.
A main objective is to develop experimental and mathematical models
that, in relation to the flow characteristic, describe the dynamics
of cell behavior and cell interactions occurring at the arterial
surface in early atherosclerosis. Focus is on the identification
of cellular and molecular mechanisms by which specific flow parameters
regulate endothelial function, contributing to localized vessel
wall remodeling and the development of atherosclerotic lesions.
Our studies combine mammalian cell models, experimental fluid dynamics,
and biochemical/molecular techniques. The detailed characterization
of the cell mechanical environment is obtained using experimental,
analytical, and numerical simulation techniques.
The novelty of our research approach reside on the fact that the
biological emphasis is in cell dysfunction and that the fluid
dynamics (and convective mass transport) emphasis is in the complex
flows found at atherogenesis-prone sites of the human vasculature.
Detailed Research Topics