Natacha DePaola, Ph.D.

  Associate Professor, Biomedical Engineering

   

Selected Publications

Refereed Journal Articles

Dewey, C.F., Jr. and DePaola, N. "Exploring Flow-cell Interactions Using Computational Fluid Dynamics". Tissue Engineering 14: 31-34, 1989.

DePaola, N., Gimbrone, M.A., Jr., Davies, P.F. and Dewey, C.F., Jr. "Vascular Endothelium Responds to Fluid Shear Stress Gradients". Arteriosclerosis and Thrombosis 12: 1254-1257, 1992.

Sanmartin, J.R., Lopez-Rebollal, O., and DePaola, N. "Non-periodic Driving of Coupled Oscillators: A Spherical Swing". Physica D 69:148-162, 1993.

DePaola, N., Gimbrone, M.A., Jr., Davies, P.F. and Dewey, C.F., Jr. "Vascular Endothelium Responds to Fluid Shear Stress Gradients". Arteriosclerosis and Thrombosis 13: 465, 1993.

LeDuc, C., DePaola, N., Konath, S.L., Vroman, L. and Leonard, E.F. "Adsorption of Proteins out of Plasma onto Glass from a Separated Flow". J.Biomater.Sci. Polymer Edn. 6(7) : 599-608, 1994.

DePaola, N. "The Effect of Shear Stress Gradients on Endothelial Cell Proliferation and Monolayer Integrity". Advances in Bioengineering 28: 321-322, 1994.

Waters, C.M., Glucksberg, M.R., DePaola, N., Chang, J., and Grotberg, J.B. "Shear Stress Alters Pleural Mesothelial Cell Permeability in Culture". J. Appl. Physiol. 81(1): 448-458, 1996.

Waters, C.M., Chang, J., Glucksberg, M.R., DePaola, N., and Grotberg, J.B. "Mechanical Forces Alter Growth Factor Release by Pleural Mesothelial Cells". American Journal of Physiology: Lung Cell. Mol. Physiol. 272(16): L552-L557, 1997.

Davies, P.F., Barbee, K.A., Volin, M.V., Robotewskyj, A., Chen, J., Joshep, L., Griem, M.L., Wernick, M.N., Jacobs, E., Polacek, D.C., DePaola, N., and Barakat, A.I. "Spatial Relationships in Early Signaling Events of Low-Mediated Endothelial Mechanotransduction". Annual Review of Physiology 59:527-49, 1997.

Davies, P.F., DePaola, N., and Polacek, D.C. "Hemodynamic Forces and Vascular Cell Communication" Atherosclerosis XI :943-948, 1998.

DePaola, N., Davies, P.F., Pritchard, W.F., Florez, L., Harbeck, N., and Polacek, D.C. "Spatial and Temporal Regulation of Gap Junction Connexin 43 in Vascular Endothelial Cells Exposed to Controlled Disturbed Flows In Vitro". Proceedings of the National Academy of Science, 96(6): 3154-3159, 1999.

Davies, P.F., Polaceck, D.C., Handen, J.F., Helmke, B.P., and DePaola, N. "Mechanotransduction and the Focal Origin of Atherosclerosis: A Spatial Approach to Gene Expression Profiling", invited paper to appear in Trends in Biotechnology , 17: 347-351, 1999.

Phelps, J.E., and DePaola, N. "Spatial Variation in Endothelial Barrier Function in Disturbed Flows In Vitro". American Jounal of Physiology: Heart and Circulatory Physiology, 278: H469-H476, 2000.

DePaola, N., Phelps, J.E., Florez, L., Keese, C.R., Minnear, F.L., Giaever, I., and Vincent, P. "Electrical Impedance of Culture Endothelium under Fluid Flow". Annals of Biomedical Engineering, (in print).

DePaola, N., Gimbrone, M.A., Jr., and Dewey, C.F., Jr. "Vascular Endothelial Response to Disturbed Flows in Vitro". Circulation Research , (reviewed, in revision).

Konath , S., LeDuc, C., DePaola, N., Vroman, L. and Leonard, E.F. "Transient Mass Transfer in Separated Flows". Int. J. Heat Mass Transfer , (reviewed, in revision).

Published Abstracts (1995-1998)

DePaola, N., Waters, C.M., Glucksberg, M.R., and Grotberg, J.B. "Shear Stress Stimulates Prostacyclin Production by Cultured Pleural Mesothelial Cells". FASEB Journal, 1995; 9(4): A717.

McKinsey, J., DePaola, N., Cybulsky, M., Davies, P.F., and Polacek, D. "Increased Venous Endothelial VCAM-1 mRNA Expression in Disturbed Flow Region Associated with Arterio-Venous Fistula in Normal and Hypercholesterolemic Rabbits". FASEB Journal, 1995; 9(3): A343.

Polacek, D., DePaola, N., Pritchard, W., and Davies, P.F. "Spatial Up-Regulation of Gap Junction Connexin43 mRNA in Endothelial Cells Exposed to Steady Laminar and Disturbed Flows In Vitro". FASEB Journal, 1995; 9(3): A267.

Chang, J., DePaola, N., Glucksberg, M.R., Grotberg, J.B., and Waters, C.M. "Endothelin Production by Mesothelial Cells is Enhanced by Shear Stress". FASEB Journal, 1995; 9(4): A716.

Burns, M. P., and DePaola, N. "Anastomotic Disturbed Flows and Endothelial Cell Function in Hybrid Vascular Grafts". Annals of Biomedical Engineering, 1995; 23:S-37.

Florez, L, McKinsey, J., Polacek, D., and DePaola, N. "3-Dimensional Velocity Fields and Shear Stress Distributions in the Localization of Intimal Thickening in Experimental Arterio-Venous Fistulas". Annals of Biomedical Engineering, 1995; 23:S-26.

DePaola, N., Davies, P.F., and Polacek, D. "Endothelial Cx43 Gene Regulation In Vitro in Disturbed Fows". Annals of Biomedical Engineering, 1996 ;24:S-48.

DePaola, N., Davies, P.F., and Polacek, D. "Endothelial Cx43 Regulation in Disturbed Flows In Vitro ". Microcirculation, 1997;4 (1): 167.

DePaola, N., Harbeck, N., Davies, P.F., and Polacek, D. "Sustained Impairment of Gap Junctional Communication in Vascular Endothelial Cells Exposed to Disturbed Fluid Flow" . Molecular Biology of the Cell, 1998;9:123a.

Florez, L, McKinsey, J., Polacek, D., and DePaola, N. "Shear Stress Distributions Predict the Localization of Intimal Thickening in Experimental Arterio-Venous Fistulas". Abstracts of the Third World Congress of Biomechanics, p. 425, 1998.

DePaola, N., Polacek, D., Florez, L., Davies, P.F., and Phelps, J.E. "Shear Stress Gradients and Endothelial Cell Function". Proceedings of the Fifth Japan-USA-Singapore-China Conference on Biomechanics, pp. 48-49,1998. (Extended Abstract).

Handen, J.S., Polacek, D., DePaola, N., and Davies, P.F. "Single Cell and Regional Endothelial Gene Expression in In Vitro Models of Flows. FASEB Journal, 1999;13(5): A857.

DePaola, N., Harbeck, N., Davies, P.F., and Polacek, D. "Endothelial Gap Junctional Communication in Disturbed Flow Conditions". FASEB Journal, 1999;13(4): A48.

Davies, P.F., DePaola, N., and Polacek, D. "Endothelial Heterogeneity in Signal Transduction of Shear Stress Responses". To be published in the Journal of Vascular Surgery, March 1999.

Davies, P.F., DePaola, N., and Polacek, D. "Endothelial Regional and Single Cell Transcriptional Profiling". Am. Soc. Nephrol. 1999.

Rizzo, V., DePaola, N., Schnitzer, J.E. and Davies, P.F. Caveolae expression regulates endothelial cell surface mechano-responsiveness. To be published in the FASEB Journal, 2000;14(4): A457.

 

 

 

 

 

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