Molecular Biochemistry II

Pentose Phosphate Pathway

Reading:

Textbook Reading: Voet & Voet, Biochemistry, 3rd Edition, p. 862-868.

Some recent articles (optional reading): 
Schellenberger, A. (1998) "Sixty years of thiamin diphosphate biochemistry," Biochim. Biophys. Acta 1385: 177-186.
Miclet, E., Stoven, V., Michels, P. A. M., Opperdoes, F. R., Lallemand, J.-Y., & Duffieux, F. (2001) "NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase," J. Biol. Chem. 276: 34840-34846.
S. Thorell, Gergely, P., Bankk, K., Perl, A., & Schneider, G. (2000) "The three-dimensional structure of human transaldolase,"  FEBS Letters 475: 205-208.
D. E. Nicholson (2001) "Pentose phosphate pathway(s) minimaps," Biochem. & Mol. Biol. Ed. 29: 179-182.
B. L. Horecker (2002) "The pentose phosphate pathway," J. Biol. Chem. 277: 47965-47971.
A. Pompella, A. Visvikis, A. Paolicchi, V. De Tata & A. F. Casini (2003) "The changing faces of glutathione, a cellular protagonist," Biochem. Pharm. 66: 1499-1503.
M. G. Tozzi, M. Camici, L. Mascia, F. Sgarrella & P. L. Ipata (2006) "Pentose phosphates in nucleoside interconversion and catabolism," FEBS J. 273: 1089-1101.

Potential Test Questions:

1. Diagram and describe the mechanism of the reaction catalyzed by the enzyme Transaldolase, including structures of major intermediates, substrates and products. 

2. Write out the linear (oxidative) portion of the Pentose Phosphate Pathway, giving names and structures of substrates and reactants, and the name of each enzyme. Summarize in words what happens at each step. What two products of the linear portion of the Pentose Phosphate Pathway have essential roles in anabolic metabolism? What are these roles?

Copyright 1998-2007 by Joyce J. Diwan. All rights reserved.

Lecture Notes on
Pentose Phosphate Pathway

Interactive Quiz on       
    Pentose Phosphate Pathway

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