Interactive
Quiz on
Pentose Phosphate Pathway
Reading:
Textbook Reading: Voet & Voet, Biochemistry, 3rd Edition, p. 862-868.
Some recent articles
(optional reading):
Schellenberger, A. (1998) "Sixty years of thiamin diphosphate biochemistry,"
Biochim. Biophys. Acta 1385: 177-186.
Miclet, E., Stoven, V., Michels, P. A. M., Opperdoes, F. R., Lallemand, J.-Y., &
Duffieux, F. (2001) "NMR spectroscopic analysis of the first two steps of the
pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase," J.
Biol. Chem. 276: 34840-34846.
S. Thorell, Gergely, P., Bankk, K., Perl, A., & Schneider, G. (2000) "The
three-dimensional structure of human transaldolase," FEBS Letters 475:
205-208.
D. E. Nicholson (2001) "Pentose phosphate pathway(s) minimaps," Biochem. & Mol.
Biol. Ed. 29: 179-182.
B. L. Horecker (2002) "The pentose phosphate pathway," J. Biol. Chem. 277:
47965-47971.
A. Pompella, A. Visvikis, A. Paolicchi, V. De Tata & A. F. Casini (2003) "The
changing faces of glutathione, a cellular protagonist," Biochem. Pharm. 66:
1499-1503.
M. G. Tozzi, M. Camici, L. Mascia, F. Sgarrella & P. L. Ipata (2006)
"Pentose phosphates in nucleoside interconversion and catabolism," FEBS J.
273: 1089-1101.
1. Diagram and describe the mechanism of the reaction catalyzed by the enzyme Transaldolase, including structures of major intermediates, substrates and products.
2. Write out the linear (oxidative) portion of the Pentose Phosphate Pathway, giving names and structures of substrates and reactants, and the name of each enzyme. Summarize in words what happens at each step. What two products of the linear portion of the Pentose Phosphate Pathway have essential roles in anabolic metabolism? What are these roles?
Copyright © 1998-2007 by Joyce J. Diwan. All rights reserved.
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