Interactive Quiz on
Microtubule Motors
Reading:
Textbook Reading: Alberts et al. 4th Edition Chapter 16. Specific pages given in the notes.
Some recent articles
(optional reading):
R. L. Karcher, S. W. Deacon & V. I Gelfand (2002) "Motor-cargo interactions: the
key to transport specificity," Trends in Cell Biol. 12: 21-27.
F. J. Kull & S. A. Endow (2002) "Kinesin: switch I & II and the motor
mechanism," J. Cell Science 115: 15-23.
E. Mandelkow & E.-M. Mandelkow (2002) "Kinesin motors and disease," Trends in
Cell Biol. 12: 585-591.
A. Kamal & L. S. B. Goldstein (2002) "Principles of cargo attachment to
cytoplasmic motor proteins," Current Opinion in Cell Biol. 14: 63-68.
D. L. Dujardin & R. B. Vallee (2002) "Dynein at the cortex," Curr. Opinion in
Cell Biol. 14: 44-49.
J. L. Rosenbaum & G. B. Witman (2002) "Intraflagellar transport," Nature Rev.
Molec. Cell Biol. 3: 813-825.
G. J. Pazour & J. L. Rosenbaum (2002) "Intraflagellar transport and
cilia-dependent diseases," Trends in Cell Biol: 12: 551-555.
S. A. Endow & D. S. Barker (2003) "Processive and nonprocessive models of
kinesin movement," Annu. Rev. Physiol. 65: 161-175.
J. M. Scholey (2003) "Intraflagellar transport," Annu. Rev. Cell Dev. Biol. 19:
423-443.
S. M. King (2003) "Organization and regulation of the dynein microtubule motor,"
Cell Biol. Internat. 27: 213-215.
S. P. Gross (2003) "Dynactin: coordinating motors with opposite inclinations,"
Current Biol. 13: R320-R322.
T. A. Schroer (2004) "Dynactin," Annu. Rev. Cell Dev. Biol. 20: 759-779.
E. P. Sablin & R. J. Fletterick (2004) "Coordination between motor domains in
processive kinesins," J. Biol. Chem. 279: 15707-15710.
C. L. Asbury, A. N. Fehr & S. M. Block (2003) "Kinesin moves by an asymmetric
hand-over-hand mechanism," Science 302: 2130-2134.
R. A. Cross (2004) "The kinetic mechanism of kinesin," Trends in Biochem. Sci.
29: 301-309.
M. J. Wozniak, R. Milner & V. Allan (2004) "N-Terminal kinesins: many and
various," Traffic 5: 400-410.
M. Sakato & S. M. King (2004) "Design and regulation of the AAA+
microtubule motor dynein," J. Struct. Biol. 146: 58-71.
M. A. Welte (2004) "Bidirectional transport along microtubules," Current Biol.
14: R525-R537.
G. C. Rogers, S. L. Rogers & D. J. Sharp (2005) "Spindle microtubules in flux,"
J. Cell Sci. 118: 1105-1116.
P. J. Hollenbeck & W. M. Saxton (2005) "The axonal transport of mitochondria,"
J. Cell Sci. 118: 5411-5419.
1. a. Diagram and describe the structure of kinesin I (conventional kinesin), and indicate the roles of different parts of the kinesin
molecule. Describe and explain the significance of the conformational
change associated with phosphorylation/dephosphorylation of the kinesin light
chains or binding and unbinding of cargo.
b. What is meant by the statement that movement of kinesin I along a microtubule
is processive? How is a processive mechanism of movement suited to the role of
kinesin?
c. Briefly describe the structure and composition of the motor domain of dynein.
Briefly describe two ways in which the dynein motor domain differs from that of kinesin.
Copyright © 1999-2006 by Joyce J. Diwan. All rights reserved.
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