CHEM-4790

Protein Chemistry

The ability to design synthetic proteins from first principles (de novo design) is a new area of protein chemistry with exciting potential applications in medicine and industry. This course will review our present understanding of chemistry and physics of protein structure and stability and show how this understanding can be applied to the design of unnatural proteins. The course will also cover the computer modeling and chemical synthesis of proteins, how to impart new characteristics to natural proteins via chemical modification, and the generation of protein ‘chimera’ using semisynthesis. Prerequisite: CHEM-4760 or BCBP-4760 or BIOL-4760 or equivalent; CHEM-6190 or BCBP-4810 is an asset. Students cannot receive credit for this course and BCBP-6790 or CHEM-6790. Recommended for seniors; juniors should talk to the instructor before registering. Spring term, odd-numbered years.

4 credit hours