CHEM-4780

Protein Folding

The biophysical mechanism of protein folding and the role of misfolding in human disease is explored. The course will introduce principles of protein structure, protein folding in the cell, and thermodynamic and kinetic methods for studying protein folding in vitro. The course will also involve a literature-based discussion of human diseases related to protein folding defects, including Alzheimer’s and other amyloid diseases, cystic fibrosis, and Prion-related syndromes. Prerequisite or corequisite: CHEM-4760 or BCBP-4760 or equivalent. Students may not receive credit for this course and BCBP-4780 or BCBP/CHEM-6780. Fall term odd-numbered years.

4 credit hours