A student at Rensselaer has developed a new method for harnessing the enormous potential of nanoparticles, which could lead to a new generation of medical devices, drug delivery technologies, and other applications.
Yuehua “Tony” Yu, a doctoral student in the Department of Chemistry and Chemical Biology, is the first researcher to create binary guanosine gels, or G-gels, with unique, highly tunable properties. The discovery, which could enable a practical, cost-effective, and scalable method for better exploiting the beneficial properties of many nanoparticles, earned Yu the $30,000 Lemelson-Rensselaer Student Prize.
“Future global challenges will demand leaders who are not only skilled scientists and engineers, but also innovators adept at problem solving and out-of-the-box thinking. The Lemelson-Rensselaer Student Prize recognizes ingenuity and inventiveness, while inspiring students toward excellence,” said Rensselaer President Shirley Ann Jackson. “Yuehua Yu is a shining example of this innovative spirit. A keen thinker and passionate researcher, he enjoys a rich understanding of technology, as well as a sharply focused determination to use his abilities for the betterment of all. We celebrate his achievement, and applaud all of the finalists for their dedication and effort. May they, and all of us, continue to foster a healthy scientific curiosity, and an unyielding drive for progress.”
Yu is the third recipient of the $30,000 Lemelson-Rensselaer Student Prize. The prize, first given in 2007, is awarded annually to a Rensselaer senior or graduate student who has created or improved a product or process, applied a technology in a new way, redesigned a system or in other ways demonstrated remarkable inventiveness.
Helping Hand for Nanotech
Breakthroughs in nanotechnology hold the promise of touching and revolutionizing medicine, energy production and storage, water purification, electronics, and a host of other diverse fields. A key challenge for many researchers working with nanoparticles is simply getting the nanoscopic materials some of which measure only a few billionths of a meter in lengthwhere they need to go. Using liquid to disperse nanoparticles seems like a natural fit, but most materials have a tendency to aggregate, or clump together, when placed in liquids. Current solutions for properly dispersing nanomaterials in liquid often impact the materials’ properties, cause irreversible damage, or result in concentrations too low to be effective.
To address this problem, Yu investigated guanosine gels, or “G-gels.” Yu was the first researcher to develop a G-gel comprised of more than one guanosine compound. He discovered that some of these new binary G-gels were liquid at low temperature, but formed firm gels when heated to room or body temperature. Further study showed that binary G-gels were highly tunable.
This ability to easily convert the G-gels from liquid to gel, and back again, was a natural fit for the reliable delivery of nanoparticles. Yu’s G-gels proved to be an inexpensive and scalable means to gently, nondestructively disperse single-walled carbon nanotubes (SWNTs) and other nanoparticles at a high concentration. By simply controlling the temperature, Yu engineered G-gels that can selectively solubilize specific SWNTs, and then be easily removed from the site after the SWNTs are in place. The gels can be tuned to selectively solubilize SWNTs based on different properties, including conductivity and structure.
Yu joined Rensselaer as a doctoral student in 2004, after earning his bachelor’s degree in chemistry and master’s degree in polymer science from Nankai University in China. In early 2005 he joined the research group of Professor Linda McGown, who heads the Department of Chemistry and Chemical Biology.
“Tony is one of the most brilliant and most creative students with whom I’ve ever worked. The elegance and simplicity of his inventions belie their novelty and ingenuity,” said McGown, who is also Yu’s academic adviser. “It’s been a privilege to work with such a gifted scientist.”
In his time at Rensselaer, Yu has filed for two patents related to his G-gel research, co-authored two journal papers, and delivered 10 presentations. He received the prestigious Rensselaer 2008 Founders Award for of Excellence, as well as the 2008 Slezak Memorial Fellowship and Baruch ’60 Award for Excellence in Energy-Related Research from Rensselaer.
The $30,000 Lemelson-Rensselaer Student Prize is funded through a partnership with the Lemelson-MIT Program, which has awarded the $30,000 Lemelson-MIT Student Prize to outstanding student inventors at MIT since 1995. The program recognizes outstanding inventors, encourages sustainable new solutions to real-world problems, and enables and inspires young people to pursue creative lives and careers through invention.
Jerome H. Lemelson, one of U.S. history’s most prolific inventors, and his wife, Dorothy, founded the Lemelson-MIT Program at the Massachusetts Institute of Technology in 1994. It is funded by the Lemelson Foundation, a philanthropy that celebrates and supports inventors and entrepreneurs in order to strengthen social and economic life in the U.S. and developing countries.
For videos and photos of the winner and award finalists, as well as a Webcast of the announcement ceremony, go to www.eng.rpi.edu/lemelson.
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